UWA Handbook 2017

Unit details

CHEM3305 Biological Chemistry

Credit 6 points
  Offering
(see Timetable)
AvailabilityLocationMode
Offshore teaching periodSingaporeFace to face
Content This unit involves the study of enzymes, primary and secondary metabolism and natural products chemistry from an organic chemist's perspective. Topics include enzymes as catalytic proteins; how enzymes enhance reaction rate and achieve substrate and product (stereo)selectivity; mode of action and inhibition, enzymes as reagents for synthesis; primary metabolism including photosynthesis, the Calvin cycle, glycolysis, fermentation, the citric acid (Krebs) cycle and amino acid biosynthesis; secondary metabolism including building blocks and mechanisms of construction; biosynthetic pathways to natural products, the acetate pathway (fatty acids and polyketides); the shikimate pathway; terpenes from the mevalonate and non-mevalonate pathways; alkaloids, peptides, proteins and carbohydrates; bioactive natural products, pharmaceuticals, medicinal compounds; production and manipulation of biosynthetic pathways; nutriceuticals, agrochemicals; chemical ecology, pheromones, defence substances, elicitors; and marine natural products.
Outcomes Students learn that the chemistry underlying life is complex but that this complexity can be understood using the tools and rules that apply to synthetic chemistry. Synthetic laboratory skills are further honed.
Assessment This comprises a mid-semester examination (35 per cent), end-of-semester examination (35 per cent) and laboratory work (30 per cent).

Supplementary assessment is not available in this unit except in the case of a bachelor's pass degree student who has obtained a mark of 45 to 49 and is currently enrolled in this unit, and it is the only remaining unit that the student must pass in order to complete their course.
Unit Coordinator(s) Associate Professor Matthew Piggott and Dr Scott Stewart
Unit rules
Prerequisites: CHEM2210 Structure Determination and Physical Chemistry; CHEM2221 Biological and Medicinal Chemistry
Advisable prior study: CHEM2211 Synthetic and Materials Chemistry
Contact hours lectures: 26 x 1 hour; labs: 36 hours, as per timetable
Unit Outlinehttp://www.unitoutlines.science.uwa.edu.au/Units/CHEM3305/TS-OFF-G3/2017
Text

Clayden, J. et al. Organic Chemistry, 2nd edn: Oxford University Press 2012

Recommended
reading

Dewick, P. Medicinal Natural Products: A Biosynthetic Approach: John Wiley & Sons Ltd 2009

Mann, J. Chemical Aspects of Biosynthesis: Oxford University Press 1994

Dobson, C. M. et al. Foundations of Chemical Biology: Oxford University Press 2001


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