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PHCY5619 Medicinal Chemistry for Pharmacy

6 points
(see Timetable)
Semester 2UWA (Perth)Face to face
This unit consolidates concepts introduced in PHCY5618 Pharmaceutical Chemistry and Analysis as well as PHCY5610 Physical Pharmacy and Biopharmaceutics. It focuses on the relationships between chemical structure and biological activity of various drugs. Emphasis is on basic principles, broad structure–activity relationships and the mechanisms of action (where known) of a range of important drugs in a number of classes (e.g. antibacterials and antivirals, anticancer drugs, cholinergics and adrenergics, steroids and analgesics) as well as the chemical strategies that have been adopted to optimise their activity. These concepts also require an appreciation of the chemistry of proteins and nucleic acids as these macromolecules constitute common drug targets. Further, the unit introduces students to the drug development process and explores sources of lead compounds as well as strategies of lead optimisation. Additionally, technical and analytical skills in methods commonly employed in drug isolation, identification and analysis are acquired and refined.
Students are able to (1) appreciate the many facets of the drug development process; (2) be familiar with the chemistry of proteins and nucleic acids as common drug targets; (3) understand the various ways in which drugs interact with their biological target; (4) recognise and classify a number of drug structures and predict their in vivo behaviour and activity; (5) describe structure–activity relationships and the mechanism of action of various drugs at the molecular level; (6) understand how physiochemical properties of drugs affect their principal therapeutic applications and/or toxicity, stability, absorption, distribution, metabolism and excretion; and (7) competently demonstrate technical and analytical skills in methods commonly employed in drug isolation, identification and analysis.
Indicative assessments in this unit are as follows: (1) laboratory assessments; (2) tests; and (3) final examination. Further information is available in the unit outline.
Unit Coordinator(s)
Associate Professor Connie Locher
Unit rules
enrolment in the Master of Pharmacy
Contact hours
lectures: 39 hours; tutorials/case studies: 9 hours; labs: 18 hours

Patrick, G. L. An Introduction to Medicinal Chemistry, 6th edn: Oxford University Press 2017

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