PUBH5742 Fundamentals of Genetic Epidemiology

6 points
Not available in 2020UWA (Perth)Face to face
This is an introductory unit covering background and methods relevant to the analysis of genetic data in epidemiological studies, with emphasis on gene mapping. Topics covered include basic population genetics, linkage analysis, family and population based association analyses, epigenetic and transcriptomic, and integrative genomic study designs for gene discovery in complex human diseases. Students gain exposure to some of the methods and computer tools available for gene mapping and genetic analysis, and begin to read and evaluate genetic epidemiological literature.
Students are able to (1) possess an overview of the current state-of-the-art in genetic epidemiology, sufficient to critically interpret the literature on gene discovery in complex human disease; (2) understand the biological and statistical principles underlying modern gene discovery, and the research methods for the study of genetic risk factors in epidemiology; (3) understand sources of error in genetic epidemiology, the difference between confounding and effect modification in genetics, and the strengths and limitations of the available study designs for genetic epidemiological research; (4) perform basic statistical analyses on genetic data including family-based association analyses, and haplotypic analysis; (5) understand the public health applications of complex disease genetics; and (6) write a report on a study in 'genetics' format.
Indicative assessments in this unit are as follows: (1) two take-home essays; (2) in-class presentation; and (3) three in-class practicals. Further information is available in the unit outline.

Supplementary assessment is not available in this unit.
Unit Coordinator(s)
Dr Phillip Melton
Unit rules
Advisable prior study:
PUBH4403 Epidemiology I, PUBH4401 Biostatistics I
Contact hours
40 hours during the intensive week; 4 hours per week after that
This unit is available even years only, and when available is taught in an intensive mode.
  • The availability of units in Semester 1, 2, etc. was correct at the time of publication but may be subject to change.
  • All students are responsible for identifying when they need assistance to improve their academic learning, research, English language and numeracy skills; seeking out the services and resources available to help them; and applying what they learn. Students are encouraged to register for free online support through GETSmart; to help themselves to the extensive range of resources on UWA's STUDYSmarter website; and to participate in WRITESmart and (ma+hs)Smart drop-ins and workshops.
  • Books and other material wherever listed may be subject to change. Book lists relating to 'Preliminary reading', 'Recommended reading' and 'Textbooks' are, in most cases, available via the Booktopia Textbook Finder, which has the functionality to search by course code, course, ISBN and title, and may also be posted or available at the appropriate school's administrative offices. Where texts are listed in the unit description above, an asterisk (*) indicates that the book is available in paperback.