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Unit Overview

Description

This unit focuses on principles and concepts of pharmaceutical chemistry and the analysis of pure drugs, formulated products and drugs in biological specimen. After a brief review of the chemical characteristics of the most important functional groups in a pharmaceutical context, it introduces students to different techniques employed in the separation (e.g. liquid–liquid extraction, TLC / HPTLC, HPLC) as well as the qualitative and quantitative analysis of pure and formulated drugs (e.g. titrimetric assays, UV-Vis spectrophotometry, IR spectroscopy, NMR and mass spectrometry). It also introduces the concept of stereochemistry and illustrates in what ways it can influence drug activity and/or toxicity. Major chemical routes of drug degradation and strategies to curtail them are discussed. In this context students are also introduced to degradation kinetics and the concept of drug shelf life. The need for quality control for drugs and drug products including complementary medicines is highlighted and the associated pharmacopoeial requirements are discussed.

Credit
6 points
Offering
AvailabilityLocationModeFirst year of offer
Not available in 2025UWA (Perth)Face to face
Details for undergraduate courses
  • Level 3 core unit in the Pharmaceutical Health major sequence
Outcomes

Students are able to (1) predict the key chemical characteristics of the most important functional groups in a pharmaceutical context; (2) describe common qualitative and quantitative drug analysis and separation techniques as they apply to pure drugs, formulated products as well as drugs in biological specimens; (3) describe a range of quantitative analyses including associated calculations; (4) explain the role of stereochemistry for drug molecules and describe different stereochemical terminologies; (5) describe the major chemical routes of drug degradation, describe drug degradation kinetics and the concept of shelf life; and (6) discuss the quality control of drugs and formulated products and the role of pharmacopoeial requirements as they relate to quality control.

Assessment

Indicative assessments in this unit are as follows: (1) ongoing assessments and (2) final examination. Further information is available in the unit outline.



Student may be offered supplementary assessment in this unit if they meet the eligibility criteria.

Unit Coordinator(s)
Associate Professor Connie Locher
Unit rules
Prerequisites
enrolment in
the Master of Pharmacy
Incompatibility
Successful completion of
Unit(s) PHCY5618 Pharmaceutical Chemistry and Analysis
Contact hours
lectures: 24 hours
tutorials/pre-labs: 21 hours
labs: 21 hours
Texts

Cairns, D. Essentials of Pharmaceutical Chemistry, 4th edn: Pharmaceutical Press 2012

Watson, D. G. Pharmaceutical Analysis, 5th edn: Elsevier 2020

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  • Contact hours provide an indication of the type and extent of in-class activities this unit may contain. The total amount of student work (including contact hours, assessment time, and self-study) will approximate 150 hours per 6 credit points.