UWA Handbook 2017

Unit details

CHEM3312 Chemistry of Drug Design and Discovery

Credit 6 points
  Offering
(see Timetable)
AvailabilityLocationMode
Offshore teaching periodSingaporeFace to face
Content This unit introduces the concepts necessary for an appreciation of medicinal chemistry, thereby providing a solid background for further study and employment in the drug discovery industry. The syllabus begins with an overview of drugs and medicinal chemistry and then considers the pharmacodynamic and pharmacokinetic properties essential for useful drugs, including a survey of biological (macromolecular) targets, the energetics of drug target interactions, molecular recognition, absorption, distribution, metabolism and excretion (ADME). The process of drug discovery and design is explored, beginning with factors affecting choice of disease/biological target, the discovery of lead compounds and then progressing to principles and strategies for drug optimisation including analogue design, structure activity relationships, structure-based drug design, reducing side-effects and improving bioavailability including pro-drug strategies.
Outcomes Students learn the key concepts and principles involved in medicinal chemistry including the essential role of chemists in the drug discovery process. Laboratory skills are enhanced by practical exercises relevant to medicinal chemistry including synthetic chemistry, chromatography, basic bioassays, measurement of physiochemical properties relevant to pharmacokinetics and combinatorial chemistry.
Assessment This comprises laboratory (30 per cent), a mid-semester examination (30 per cent), an oral presentation (10 per cent) and a final examination (30 per cent).

Supplementary assessment is not available in this unit except in the case of a bachelor's pass degree student who has obtained a mark of 45 to 49 and is currently enrolled in this unit, and it is the only remaining unit that the student must pass in order to complete their course.
Unit Coordinator(s) Associate Professor Matthew Piggott
Unit rules
Prerequisites: CHEM2210 Structure Determination and Physical Chemistry and CHEM2221 Biological and Medicinal Chemistry
Contact hours lectures: 26 x 1 hour; labs: 36 hours
Unit Outlinehttp://www.unitoutlines.science.uwa.edu.au/Units/CHEM3312/TS-OFF-G6/2017
Texts

Patrick, G. L. An Introduction to Medicinal Chemistry, 3rd edn: OUP 2005


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