GENE3380 Genetic Origins of Health and Disease

Credit
6 points
Offering
AvailabilityLocationMode
Not available in 2020UWA (Perth)Face to face
Details for undergraduate courses
  • The area of knowledge for this unit is Life and Health Sciences
  • Category B broadening unit for students
  • Level 3 elective
Content
Students investigate the genetic basis of polygenic or complex traits and disorders such as diabetes, cardiovascular disease and neurological disorders with an emphasis on the current strategies that can be employed to map disease loci. A major focus is the use of next generation sequencing and quantitative transcript data using integrative or genetical genomic approaches. A further emphasis is the development of molecular prioritisation strategies leading to the identification of functional genetic variation that is causal for a particular disease phenotype. Routes to translation of functional genetic information into clinical practice are explored. Lecture topics include family studies of complex disease, association studies and linkage disequilibrium, limitations of genome-wide association studies, pathway analysis using genetic tools, and genome-wide views of disease. At the completion of the unit students are able to understand current strategies for the application of next generation sequencing studies in complex disease research and to analyse and interpret results for understanding genetic influences in complex disease. They also have an appreciation of the possible impact of complex disease genetics on the practice of medicine.
Outcomes
Students are able to (1) understand current strategies for the application of next generation sequencing studies in complex disease research; (2) understand and develop strategies to study a particular complex phenotype; (3) analyse and interpret results for understanding genetic influences in complex disease; and (4) have a practical knowledge of the technology used to generate genetic data and an appreciation of the appropriate statistical analyses to extract data.
Assessment
Indicative assessments in this unit are as follows: (1) lab worksheets and presentations; (2) mid-semester test; and (3) a final examination. Further information is available in the unit outline.

Supplementary assessment is not available in this unit except in the case of a bachelor's pass degree student who has obtained a mark of 45 to 49 overall and is currently enrolled in this unit, and it is the only remaining unit that the student must pass in order to complete their course.
Unit Coordinator(s)
Professor Lawrie Abraham
Unit rules
Prerequisites:
PATH2211 Molecular Medicine;
or
GENE2250 Principles of Inheritance;
or
PATH2210 Fundamentals of Pathology and Laboratory Medicine
Contact hours
lectures: 2 hours per week; tutorials: 5 hours per semester; labs: 3 hours per week
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  • Books and other material wherever listed may be subject to change. Book lists relating to 'Preliminary reading', 'Recommended reading' and 'Textbooks' are, in most cases, available at the University Co-operative Bookshop (from early January) and appropriate administrative offices for students to consult. Where texts are listed in the unit description above, an asterisk (*) indicates that the book is available in paperback.