PAED4408 Neonatal Infections and Immunology

6 points
Not available in 2020OnlineOnline
This unit develops students' understanding of fetal and neonatal infections, underlying risk factors, prevention, diagnostic investigations, management and long-term implications.

Specifically, the following topics are addressed: (1) fetal period—the effects of chorioamnionitis and funisitis, intrauterine transmission of infection (TORCH group), hepatitis B, C and HIV transmission and related neonatal management; (2) neonatal infections—early and late onset sepsis, risk factors, clinical features, diagnostic and adjunct laboratory investigations and management [coagulase-negative staphylococcus, Candida, respiratory syncytial virus (RSV), cytomegalovirus (CMV) and other viral infections]; (3) nosocomial infections (including colonisation/infection with multi-resistant organisms): incidence, appropriate monitoring, risk factors, preventive interventions (hand hygiene, catheter management, responsible antibiotic use, etc.); and (4) neonatal immunology—the role of innate and adaptive defences relevant to neonatal pathogens. Novel strategies for decreasing the rate of infections as well as treatments aimed at modifying the inflammatory response are discussed.
Students are able to (1) thoroughly understand the role of infection in neonatal mortality and morbidity, clinical features and management of early and late onset infection; (2) demonstrate knowledge of the short and long-term sequelae of intrauterine and perinatal infections and relevant investigations; (3) demonstrate knowledge of host immune factors contributing to the risk of infection in the fetal and neonatal periods; (4) plan the management of early and late onset sepsis including investigations, antibiotic choice, duration and the correlation of both clinical and laboratory evidence of response; (5) analyse the risks of healthcare associated infection and the steps required to minimise these; and (6) advise strategies for limiting the spread of multi-resistant organisms in a nursery and counsel parents as to their baby's risk of colonisation and infection.
Indicative assessments in this unit are as follows: (1) a two-hour multiple choice question examination at the end of the semester and (2) audit activity or research study in neonatal infection/neonatal immunology including literature review and oral presentation. Further information is available in the unit outline.

Supplementary assessment is not available in this unit.
Unit rules
Approved quota: 6—places will go preferentially to Senior Registrars and Fellows based at King Edward Memorial Hospital. If there are more than six interested students, places are allocated based on proximity to completion of their advanced training program (places going preferentially to those closest to completion).
  • The availability of units in Semester 1, 2, etc. was correct at the time of publication but may be subject to change.
  • All students are responsible for identifying when they need assistance to improve their academic learning, research, English language and numeracy skills; seeking out the services and resources available to help them; and applying what they learn. Students are encouraged to register for free online support through GETSmart; to help themselves to the extensive range of resources on UWA's STUDYSmarter website; and to participate in WRITESmart and (ma+hs)Smart drop-ins and workshops.
  • Books and other material wherever listed may be subject to change. Book lists relating to 'Preliminary reading', 'Recommended reading' and 'Textbooks' are, in most cases, available via the Booktopia Textbook Finder, which has the functionality to search by course code, course, ISBN and title, and may also be posted or available at the appropriate school's administrative offices. Where texts are listed in the unit description above, an asterisk (*) indicates that the book is available in paperback.