PHAR3320 Systems Pharmacology

Credit
6 points
Offering
(see Timetable)
AvailabilityLocationMode
Semester 2UWA (Perth)Face to face
Details for undergraduate courses
  • Level 3 core unit in the Pharmacology major sequence
  • The area of knowledge for this unit is Life and Health Sciences
  • Category B broadening unit for students
  • Level 3 elective
Content
In this unit, the academic objective is to provide students with a state-of-the-art insight into how drugs affect physiological and pathological systems. Various topics are dealt with in depth, including clinical pharmacology, clinical toxicology, immunopharmacology, respiratory pharmacology, lipid-lowering drugs, clinical trials, psychopharmacology, neuropharmacology and oxidative stress.
Outcomes
Students are able to (1) explain key concepts in immunopharmacology, in particular the pharmacological control of cells involved in inflammatory and immune responses; (2) communicate their comprehension of key concepts in respiratory pharmacology, with particular reference to understanding how drugs (with examples) can be used to limit inflammation and bronchoconstriction in asthmatic airways; (3) demonstrate a clear understanding of the structure, function and metabolism of lipids and lipoproteins, and the impact of drugs (with examples) that regulate lipoprotein metabolism on cardiovascular disease; (4) explain the key concepts in clinical trial methodology, including descriptions of the different phases of clinical trials and their principal purpose; (5) communicate their understanding of how drugs can be used to treat central nervous system (CNS) disorders including schizophrenia and depression, and how this may be modulated by chronic drug administration; (6) explain how free radicals can alter the structure and function of key cellular macromolecules including DNA, proteins and lipids, and how antioxidants (with examples) can be used to protect cells from damage by free radicals; and (7) explain key concepts in clinical pharmacology and clinical toxicology.
Assessment
Indicative assessments in this unit are as follows: (1) multiple choice questions and (2) a final examination. Further information is available in the unit outline.

Supplementary assessment is not available in this unit except in the case of a bachelor's pass degree student who has obtained a mark of 45 to 49 overall and is currently enrolled in this unit, and it is the only remaining unit that the student must pass in order to complete their course.
Unit Coordinator(s)
Associate Professor Peter Henry
Unit rules
Prerequisites:
[PHAR2210 Foundations of Pharmacology,
and
PHAR2220 Human Pharmacology];
or
[IMED2002 Blood and Drugs and one of
the following units: IMED2001 Body Defences; IMED2003 Essentials of Research in the Health and Medical Sciences or
IMED2004 Human Development and Genetics]
Incompatibility:
PHAR3303 Drugs and Disease A,
Contact hours
lectures: 3 hours per week
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