UWA Handbook 2017

Unit details

PHCY5619 Medicinal Chemistry for Pharmacy

Credit 6 points
(see Timetable)
Semester 2UWA (Perth)Face to face
Content This unit consolidates concepts introduced in PHCY5618 Pharmaceutical Chemistry and Analysis as well as PHCY5610 Physical Pharmacy and Biopharmaceutics. It focuses on the relationships between chemical structure and biological activity of various drugs. Emphasis is on basic principles, broad structure-activity relationships and the mechanisms of action (where known) of a range of important drugs in a number of classes (e.g. antibacterials and antivirals, anticancer drugs, cholinergics and adrenergics, steroids and analgesics) as well as the chemical strategies that have been adopted to optimise their activity. These concepts also require an appreciation of the chemistry of proteins and nucleic acids as these macromolecules constitute common drug targets. Further, the unit introduces students to the drug development process and explores sources of lead compounds as well as strategies of lead optimisation. Additionally, technical and analytical skills in methods commonly employed in drug isolation, identification and analysis are acquired and refined.
Outcomes Students are able to (1) appreciate the many facets of the drug development process; (2) be familiar with the chemistry of proteins and nucleic acids as common drug targets; (3) understand the various ways in which drugs interact with their biological target; (4) recognise and classify a number of drug structures and predict their in vivo behaviour and activity; (5) describe structure-activity relationships and the mechanism of action of various drugs at the molecular level; (6) understand how physiochemical properties of drugs affect their principal therapeutic applications and/or toxicity, stability, absorption, distribution, metabolism and excretion; and (7) competently demonstrate technical and analytical skills in methods commonly employed in drug isolation, identification and analysis.
Assessment Typically this unit is assessed in the following ways: (1) laboratory assessment; (2) mid-semester test; (3) cumulative tutorial test; and (4) final examination. Further information is available in the unit outline.

Supplementary assessment is not available in this unit.
Unit Coordinator(s) Associate Professor Connie Locher
Unit rules
Prerequisites: enrolment in the Master of Pharmacy (51500)
Contact hours lectures: 39 hours; tutorials/case studies: 9 hours; labs: 18 hours
Unit Outlinehttp://www.unitoutlines.meddent.uwa.edu.au/Units/PHCY5619/SEM-2/2017

Patrick, G. L. An Introduction to Medicinal Chemistry, 5th edn: Oxford University Press 2013

  • The availability of units in Semester 1, 2, etc. was correct at the time of publication but may be subject to change.
  • All students are responsible for identifying when they need assistance to improve their academic learning, research, English language and numeracy skills; seeking out the services and resources available to help them; and applying what they learn. Students are encouraged to register for free online support through GETSmart; to help themselves to the extensive range of resources on UWA's STUDYSmarter website; and to participate in WRITESmart and (ma+hs)Smart drop-ins and workshops.
  • Books and other material wherever listed may be subject to change. Book lists relating to 'Preliminary reading', 'Recommended reading' and 'Textbooks' are, in most cases, available at the University Co-operative Bookshop (from early January) and appropriate administrative offices for students to consult. Where texts are listed in the unit description above, an asterisk (*) indicates that the book is available in paperback.